I was awarded my PhD in 1991 from the University of St. Andrews after which I undertook a one-year Research Fellowship funded by the Royal Society at the Station Zoologique, Villefrance-sur-Mer, France.
I joined the University of Sheffield in 1992, first as a Postdoctoral Research Assistant and then was appointed as lecturer in 1997. In 2001 was appointed as Senior Lecturer in Andrology and in 2015 Professor of Andrology.
In addition to my academic duties, I am also the Head of Andrology for Sheffield Teaching Hospitals where I direct a busy clinical andrology laboratory and am in charge of the sperm banking service.
I am interested in the biology of human spermatozoa and aspects of semen quality and fertility in males. It is estimated that 1 in 6 couples have a problem in conceiving a child and in about half of these cases, a problem is identified with the male partner. This may be a result of too few sperm being produced, or the fact that sperm have poor motility (swimming ability) or morphology (size and shape).
In recent years, my research has focussed on how micro-organisms such as Chlamydia trachomatis interact with sperm and affect sperm function. This is in collaboration with Adrian Eley (see links) and has shown that the bacteria can trigger signalling pathways in sperm that lead to premature sperm death. We have investigated the molecular nature of this process and have recently shown that sperm washing methods currently in use in clinics are not effective in removing C. trachomatis from sperm.
In the search for better diagnostic methods in the clinic, I have recently collaborated with engineers from the University of Glasgow (Green/Gilles) and applied modelling techniques used in fluid mechanics to better understand how sperm swim. This paper was published in the Journal of Fluid Mechanics in 2008 (see below) and shows that swimming speed is closely related to the side and shape of the sperm head.
Work with Urologists in Sheffield has developed a new diagnostic test for men who have small numbers of non-motile sperm in their ejaculates following vasectomy. In some men, these sperm are present for many months or years meaning the men cannot be discharged from care or cease using contraception because it is not be certain if the surgery has been successful. We have employed a fluorescent test that allows us to determine if these sperm are dead or alive in order to discriminate between failed vasectomy and inadequate clearance of dead sperm.
Finally, I am interested in occupational and environmental influences on semen quality. In collaboration with colleagues from the University of Manchester, I conducted a large multi-centre study of semen quality at 14 clinics within the UK, relating measures of semen quality to. In 2008 we published the first paper describing how occupational exposure to glycol ethers (found in paints) was associated with a low motile sperm count. Further papers from this data are being prepared and will be published shortly.
I lecture in Phase 1b (GU and Endocrine) and Phase 3 (Women´s Health) of the Bachelor of Medicine and Bachelor of Surgery (MBChB) course. I also contribute to the Student Selected Components of Phase 1a (Critical Analysis) and Phase 1b (Research Methods) and offer B. Med. Sci., projects. Outside the Medical School, I lecture on Module MBB 331 (Gametes and Embryos) in the Department of Molecular Biology and Biotechnology and also the APS 120 (Reproduction and Development) module in the Department of Animal and Plant Sciences. I am also the Course Director and Admissions Tutor for the MSc in Science Communication which is starting in the Autumn of 2011 (see links).
I am currently a member of the Editorial Board of `Reproduction´ (Society for Reproduction and Fertility) and `Human Fertility´ (Informa Healthcare). I am a trustee of the British Fertility Society Educational Trust (2001 to present), a member of the Advisory Council of the National Gamete Donation Trust (2001 – present) and Chairman of the UK NEQAS Andrology Steering Group (2004 – present). I am currently a member of an Advisory Group to the Human Fertilisation and Embryology Authority as part of their 'Donation Policies Review'.
Director of the Cryopreservation Laboratory
Speciality: IVF Laboratory
IVI Clinic Valencia
Graduate in Bacteriology and Clinic Laboratory. Master's Degree in Biological Sciences, with honours in Biology of Reproduction from the University of Chile, 1994. Pre-doctoral position as an embryologist at IVI Valencia since 1995. Master's Degree in Human Reproduction from the University of Valencia, 2003.
IVF laboratory embryologist and Director of the Cryobiology and Cryopreservation Unit.
Head of the Continuous training on Cryopreservation of Oocytes and embryos Department at IVI-University of Valencia. Associate Professor at the Master's Degree in Human Reproduction at the Rey Juan Carlos University in Madrid.
Awards and merits:
Organiser of the 1st and 2nd CRYO International Conference. Member of the SEF, ESHRE, ASEBIR and Executive Member of the ALPHA Scientists in Reproductive Medicine.
Research and scientific activity:
Different research projects funded by the regional and state Government, over 47 presentations given at conferences, 4 books as a co-editor, 30 book chapters and 45 original articles in international journals with impact factor
Professor Lambalk’s research interests include neuroendocrinology of reproduction with a focus on interaction between brain function and reproductive hormones, GnRH analogs, physiology of natural twinning, reproduction with ageing and after cancer survival, polycystic ovarian syndrome and embryo quality and embryo implantation.
He is currently a gynaecologist/fertility specialist with a focus on reproductive endocrinology and since 1992 has been based at the Division of Reproductive Medicine, VU University Medical Center (VUmc) in Amsterdam. Since October 2009, Professor Lambalk has been Guest Professor of Reproductive Medicine and Obstetrics at the University of Gent in Belgium.
Professor Lambalk has published over 100 papers and book chapters on subjects related to his research interests. He is editorial board member of Twin Research and RBM Online and the Journal of Human Reproductive Science, emeritus associated editor for Human Reproduction, associated editor of the Journal of Human Reproduction, editorial consultant for the Lancet. He is member of the Dutch Society of Reproductive Medicine (DSRM), the European Society of Human Reproduction and Embryology (ESHRE), the Endocrine Society, the American Society of Reproductive Medicine (ASRM) and the International Society on Twin Studies (ISTS).
Carmen García received her Bachelor´s degree in Biology and a PhD in Biotechnology at the University of Valencia. She also has a Master degree in Human Assisted Reproduction at InstitutoUniversitario IVI (Valencia, Spain).
Her research has been carried out mainly in Fundación IVI under the supervision of Dr. Carlos Simón and Dr. Antonio Pellicer. This research has been focused on one hand on the understanding of ovulation and early pregnancy regulation, and on the other hand on the study of several gynecological diseases such as endometriosis, leiomyoma and ovarian cancer. Besides, Carmen García has an international profile, with research appointments in important laboratories such as Florida State University (Florida, EEUU) and KarolinskaInstitutet (Stockholm, Sweden). In this last laboratory, Carmen García was able to get a prestigious Marie Curie post-doc fellowship awarded by the European Union. During her stay in Stockholm she studied the relationship between endometriosis-stem cells-ovarian cancer, also the possible use of human embryonic stem cells (hESC) in order to study embryo implantation. Her research has been published in main peer-reviewed specialist journals in the field such as Fertility and Sterility and Human Reproduction.
At clinical setting she has extensive experience in the study of chromosomal abnormalities in embryos using NGS (Next-Generation Sequencing) technology at the Preimplantation Genetic Screening Laboratory placed in Igenomix (Valencia, Spain). She was also lab manager of IGENOMIX México for more than a year.
At present, she is working in Igenomix Valencia in the PGS research department.
BC Women’s Centre for Pelvic Pain & Endometriosis
Dr. Allaire graduated with honours from McGill University in 1990. She moved to Vancouver to follow her passions and to pursue specialty training in Obstetrics & Gynecology at University of British Columbia. After completing her Residency in 1995, she then completed a Fellowship in Minimally Invasive Surgery (MIS) at Baylor College of Medicine in Texas. Dr. Allaire is Clinical Professor at UBC Department of Obstetrics & Gynaecology, Division of Gynaecologic Specialties and in the Division of Reproductive Endocrinology and Infertility (REI/IVF). She is the creator and director of the MIS rotation, is the Director of the UBC Fellowship in Endometriosis, Pelvic Pain, and Advanced Laparoscopy, and is known across Canada and internationally as a teacher and mentor in MIS.
Dr. Charles Bormann is associate director of the clinical laboratory of assisted reproduction at Brigham and Women’s Hospital. Dr. Charles obtained his BSc from Iowa State University at 1999; his MSc and PhD in Reproductive Physiology was obtained from University of Connecticut at 2004 and 2005.
Dr. Charles is the member of ASRM, past president of SRBT, Executive Board Member of New England Fertility Society, Chair of Director Board of ESHRE, and Chair of Laboratory Director Committee of SART.
He also is the reviewer of Fertility and Sterility, Human Reproduction, American Journal of Obstetrics and Gynecology, Reproductive Biomedicine Online, Journal of Assisted Reproduction and Genetics and Reproductive Sciences.
Professor Barratt is Head of the Reproductive Medicine Group at the University of Dundee as well as a clinical scientist (Hon) with NHS Tayside. He graduated with an Honours degree in Zoology and then completed a Post Graduate Certificate in Education (University of Wales, Swansea). His PhD, also in Zoology, was under the supervision of Jack Cohen (sperm selection fame) at the University of Birmingham.
His formative post-doctoral studies and IVF experience was gained at the University of Sheffield [with Ian Cooke] where they specialized in natural cycle IVF.
From 1997-2005 he was the Scientific Director of the ART Centre at the Birmingham Women’s Hospital. In 2002 he was awarded Young Andrologist of the Year (American Andrology Society) for outstanding contributions to the discipline.
He is a regularly invited speaker at national and international scientific conferences/workshops. He was a member of the WHO Male Fertility Semen Analysis Taskforce (for both the 4th and 5th editions) and is now director of the new WHO (2012-2016) Male Fertility Expert Working Group which is devising a new system for the diagnosis and treatment of the infertile male. He was a member of the Human Fertilisation and Embryology Authority for 6 years.
He has been on the Editorial Board of Human Reproduction, Human Fertility, Biology of Reproduction, Human Reproduction Update and Journal of Andrology. In 2014 Professor Barratt presented the Professor Sir Robert Edwards keynote lecture at ESHRE. This presentation was based on the highest downloaded paper in Human Reproduction for 2013. Currently he is Editor-in-Chief of Molecular Human Reproduction (Impact factor 5 year 3.9). His life’s ambition is to see - live - Wales comprehensively beat the All Blacks.
Professor, Department of Obstetrics, Gynecology and Women's Health (OBGYN)
Dr. De Jonge is the Senior Director of Laboratory Operations, ReproductiveMedicine Center.
He is a board-certified High-complexity Clinical Laboratory Director with the American Board of Bioanalysis and a board-certified Embryologist with the American College of Embryology.
He has served on many national and international bodies that are responsible for establishing laboratory standards including the World Health Organization.
Dr. De Jonge received his Ph.D. from the Department of Physiology at Rush University in Chicago and completed a Post-Doctoral Fellowship in Reproductive Endocrinology/ Infertility from that same institution.
Awards & Recognition
Co-investigator/author of research publication cited by TIME magazine as 2010 Top Ten Medical Breakthroughs, 2010
British Medical Association Medical Book Competition. “Highly Commended” Obstetrics & Gynaecology for “The Sperm Cell: Production, Maturation, Fertilization, Regeneration.”, 2007
American Society of Andrology, "Young Andrologist Award", 1995
Outstanding Achievement, College of Medicine, University of Nebraska Medical Center, 1994
The Graduate College Award, 1989
Stage-Specific Genomic Characterization of Human Preimplantion Embryos
Molecular Genetic Analysis of Human Imprinting and Assisted Reproduction
Human oocyte and ovarian tissue cryopreservation
For a list of publications, see PubMed.
Wong CC, Loewke KE, Behr B, Bossert NL, Raja R, De Jonge CJ, Baer TM, ReijoPera R (2010). Correlated time-lapse imaging and single-cell gene expression in human embryogenesis. Nat. Biotechnol. 28, 1115–1121.
De Jonge CJ (2005). Biological basis for human capacitation. Human Reprod Update 11:205.
Doherty CM, Tarchala SM, Radwanska E, De Jonge CJ (1995). Characterization of two second messenger pathways and their interactions in eliciting the human sperm acrosome reaction. J Androl 16:36.
Reproductive Medicine Center
Embryologist, American College of Embryology;
High Complexity Clinical Laboratory Director, American Board of Bioanalysis
During this study, Dr Cristina Hickman was the Head of Embryology at Boston Place Clinic where she designed the first IVF clinic in the World around the Time-Lapse technology. She is currently a lecturer at Imperial College London and Scientific Representative of the British Fertility Society.
Dr Cristina Hickman has over 15 years of research and clinical embryology experience. She has developed her research skills as a member of scientific teams in the USA (Florida University), Ireland (Galway University), England (University of Southampton, Imperial College London), Scotland (Scottish Agricultural College, University of Edinburgh, University of Aberdeen, Roslin Institute) and the Caribbean (University of Trinidad and Tobago). After completing her PhD from University of Edinburgh, she completed the Association of Clinical Embryology certification at one of the largest IVF clinics in the UK (Manchester CARE Fertility). She was appointed Scientific Director of Trinidad and Tobago IVF and Fertility Centre before joining Boston Place Clinic, part of The Fertility Partnership (the largest group of IVF clinics in the UK), as Head of Embryology, where she designed the first UK clinic to offer Embryoscope culture to all patients. She has also designed and seen to completion six innovative new IVF laboratories in the Middle East, the Caribbean and the UK as well as consulted with IVF clinics worldwide. She co-authored a paper developing the first algorithm to predict embryo viability and has since been invited to present her research at ESHRE, Alpha, ASRM, ASPIRE, Fertility and other top conferences in the IVF Field
Brief biographical sketch of the Coordinator
1) Graduated at the Faculty of Medicine and Surgery (MD) 110/110 cum laude University of Florence
2) “Specialist in Endocrinology and Metabolic Diseases” Maximum marks cum laude (30/30 cum laude) University of Florence, Faculty of Medicine 70/70 cum laude
3) “Clinical Andrologist” of the European Academy of Andrology
4) PhD in Human Genetics (“Mention Très honorable avec felicitations du Jury”); Université Paris VII, Pasteur Institute, Paris, France; Title of the Thesis: “Y chromosome and male infertility”
5) PhD in “Endocrinology and Metabolism” University of Florence, Faculty of Medicine
Member of the scientific board of the Doctorate/PhD Program in :
1) SCIENZE BIOMEDICHE, University of Florence, Italy
Member of the following Scientific Societies
1)Academician” of the European Academy of Andrology (EAA) from 2014 President of the EAA
2) Member of the SocietàItaliana di Endocrinologia (SIE) from 2013 member of the Executive committee
3) Member of the SocietàItaliana di AndrologiaMedica e Sessuologia (SIAMS)
4) Honorary Member of the Hungarian Society of Andrology (MATT)
5) Honorary member of the Hungarian Oncology Society (MOT)
Member of the editorial board of the following Journals
1) from 2004-2014 International Journal of Andrology (Associate Editor)
2) from 2004-2007 Human Reproduction (Associate Editor)
3) from 2017 Human Andrology (Associate Editor)
4) from 2013 Basic and Clinical Andrology (Associate Editor)
5) from 2014 Andrology (member of the Editorial board)
1) Vinci Serena, Post-doc, Biotechnologist
2) Guarducci Elena, Biologist
3) Casamonti Elena, PhD-student, Biotechnologist
4) Cioppi Francesca, Master Student, Biotechnologist
5) Fino Maria Grazia, biomedical laboratory technician (onco-andrology, spermatology)
6) Selene Degl’Innocenti, biomedical laboratory technician (Y chromosome analysis)
Current research interests The laboratory is dedicated to the identification of genetic factors involved in male infertility, cryptorchidism and testis cancer. The main topics are Y chromosome rearrangements and Y-linked gene copy number variations in relationship with the above pathologies. Given the specific competencies of the laboratory in Y chromosome rearrangements, the laboratory organized a multicenter study aimed to define the genetic determinants for the variable phenotype of gr/gr deletion carriers. The second relevant research topic is on genetic polymorphisms (SNPs, microsatellites and CNVs. A project on X-linked copy number variations, using a high resolution array-CGH, we are able to identify copy number variations (losses and gains) on the X chromosome with potential effect on spermatogenesis. The majority of the research projects performed in this laboratory have a clear translational feature and are aimed to implement the available diagnostic tests in male infertility. Genetic studies in men with impaired spermatogenesis are relevant also for the potential transmission of genetic anomalies to the next generation through Assisted Reproductive Techniques. Studies focusing on genetic factors involved in testis tumors are relevant for the prediction of genetic risk for this disease.
An other kind of activity carried out in our laboratory are pharmacogenetic studies on three SNPs on FSHβ and FSHR in oligo- and/or astheno- and/or teratozoospermic patients. We are evaluating the effect of cytostatic therapy on the male gamete genome . The ultimate goal of the project is to define reproductive safety in oncological patients and thus provide evidence based information for decision making concerning the type of conception (pre-therapy frozen/thawed spermatozoa in the context of in vitro fertilization) or natural pregnancy (spermatogenesis is recovered in about 80% of patients after chemotherapy).
Current / recent sources of funding
1) IstitutoToscanoTumori (ITT)
2) EnteCassa di Risparmio di Firenze (2015)
3) PRIN 2017-2020, Italian Ministry of Instruction and Research
Daniela Romualdi completed her Ob/Gyn residency in 2006 and her fellowship training in Physiopathology of Human Reproduction in 2010. She is currently consultant at Department of Women’s and Children’s Health, University General Hospital AgostinoGemelli in Rome, Italy. Her clinical research activity is focused on the physiopathology of human reproduction, endocrinologicalgynaecology and reproductive surgery. Daniela is currently Senior Deputy, and Coordinator elect, of the ESHRE SIG Reproductive Endocrinology.
President and co-owner of Oozoa Biomedical. During the last 24 years he has provided a wide range of consultancy in various areas of reproductive biology and medicine in human, domesticated and laboratory species covering products, equipment and services from both the diagnostic and therapeutic perspectives.
Major projects have included setting up state-of-the-art IVF centres, andrology laboratories and cryobanks, based on the principles of Total Quality Management.
Born and raised in the UK, his tertiary education was in Zoology (Bristol University) and a PhD from Edinburgh University followed by postdoctoral training in Edinburgh, Paris and Birmingham.
In 1983 he was appointed Assistant Professor in the Departments of Obstetrics & Gynaecology and Medical Physiology at the University of Calgary, supported by the Alberta Heritage Foundation for Medical Research. His laboratory investigated human sperm pathophysiology and, as Scientific Director of the Infertility Programme, he was responsible for developing diagnostic andrology services and one of the largest sperm banks in Canada. Following several promotions he was cross-appointed to the Department of Pathology and taught each year in the Reproductive System Course, acting as Course Chairman and in an advisory capacity to the WHO in preparing the 3rd (1992) edition of their Laboratory Manual, and Editor for the first two editions of the Canadian Fertility & Andrology Society’s Donor Insemination Guidelines.
In 1991 he moved to Sydney (Australia) as the Scientific Director of Sydney IVF (“SIVF”) where he was responsible for the development of assisted reproduction laboratory services at their other sites in Australia and around South East Asia. During this time he developed new sequential IVF culture media and incubators that provided SIVF with the highest success rates in Australia, and which have since been commercialized by SIVF as the Cook Culture System. In Sydney he held honorary appointments as Clinical Senior Lecturer in Obstetrics & Gynaecology at Sydney University, and Visiting Principal Scientific Officer in the Reproductive Endocrinology & Infertility Department of the Royal Prince Alfred Hospital. In 1997–99 he worked on the World Health Organization’s "Manual for the Standardized Investigation, Diagnosis and Management of the Infertile Male" (Cambridge University Press, 2000).
From a business perspective, he was Managing Director of Mortimer Scientific Consulting Pty Ltd, a founding partner in Andrology International BV, and Scientific Director and Board Secretary of Launceston.SIVF Pty Ltd. He has also served on Scientific Advisory Boards for several biotechnology companies before returning to Canada and establishing his consulting company, Oozoa Biomedical Inc., of which he is President.
Dr. Mortimer has authored/co-authored over 130 scientific publications, including the books "Practical Laboratory Andrology" (Oxford University Press, 1994), "Quality and Risk Management in the IVF Laboratory" (Cambridge University Press, 2005), and "A Practical Guide to Basic Laboratory Andrology" (Cambridge University Press, 2010), as well as numerous conference presentations.
His current h-index (Thomson ISI Web of Knowledge) is 26. He has given many invited lectures, workshops and courses worldwide, and was a founder of the ESHRE Basic Semen Analysis courses.
He is a member of numerous national or international professional societies, Editorial Boards, including Human Reproduction and as Associate Editor for Human Reproduction Update, the highest-ranked reproductive biomedicine journal, since January 2011. He was Scientific Programme Chairman for the 11th World Congress on In Vitro Fertilization and Human Reproductive Genetics held in Sydney (Australia) in May 1999, and co-edited the plenary proceedings volume "Towards Reproductive Certainty: Fertility and Genetics Beyond 1999" (Parthenon Press).
He is the current Past-President of the Canadian Fertility & Andrology Society (CFAS) having served as the President and Secretary/Treasurer. He has also served on committees for the Canadian Standards Association and with Accreditation Canada
Ph.D., HCLD (ABB)
Dean is the Scientific Director for Fertility Associates and is a Lecturer at the University of Auckland.
He is actively involved with research, focusing on in vitro stress during embryo culture, specifically, identifying sources of stress and developing improved methods for detection and prevention of factors that cause stress during preimplantation embryo culture.
Dr. Morbeck is actively investigating the benefits of time-lapse imaging for improving conditions and providing better embryo selection.
Prior to joining in 2016, Dr. Morbeck spent 10 years at the Mayo Clinic and prior to that over 10 years as a laboratory director in private practice, first in Ohio and then in Minnesota. For three years (2004-2006) he functioned independently as an off-site director/consultant at several clinics across the US.
Clinics: National Management Group
Did his Ph.D. degree in reproductive physiology from the University of Utah, his M.S. degree in cellular and developmental biology from Brigham Young University. He has worked in the area of research and treatment of human infertility for 35 years he also directs a number of post-doctoral fellows, Ph.D. graduate students, and research personnel, he is an international leader in the field genetic aspects of male infertility and early embryogenesis, He has authored more than 225 research papers and book chapters, and has edited 8 medical books related to infertility
The mysteries of conception are this researcher's passion. As a young biologist, Professor Eileen McLaughlin produced her first test tube baby in 1983, just five years after Louise Brown was heralded as the world's first IVF birth. It was a case of 'right time, right place' for McLaughlin, who graduated from the University of Glasgow to research positions involving assisted reproduction at the universities of Birmingham and Bristol at a time when Britain was the international hot spot in this emerging field. That experience was the foundation for what has become a distinguished research career in reproductive science. McLaughlin's work has been recognised with awards from the British Fertility Society and the Society for Reproductive Biology in Australia and has been published in esteemed medical journals including Cell and The Lancet. Since joining the University's reproductive science group in 2001, a focus of McLaughlin's research has been the fertility prospects of older women. She says her research has reinforced the theory that declining egg quality, rather than quantity, is the major hindrance to conception in women in their late 30s and older. While science has not delivered a magic formula to improve the quality of mature eggs, McLaughlin is researching the way oocytes, or immature egg cells, are 'woken' to be released from the ovary. The aim is that better understanding this process could lead to new ways of harvesting or prolonging the life of good eggs. "The attrition rate of eggs is very high," she says. "A female has about 1 million eggs at birth but by the time she is in her mid 30s she is down to about 20,000. By the age of 40, she will have a few thousand," she says. "She will only ovulate 400 eggs in her life, so the vast majority of them are wasted. The challenge is to find a way to a hold on to some of those good eggs longer." McLaughlin's work has established that many chemicals used in everyday items such as glues, dyes and pesticides, are potentially toxic to eggs, which can further frustrate the efforts of older mothers to conceive.There are increasing numbers of women in their 30s who are having difficulty producing a sufficient number of good eggs to conceive. The evidence suggests that this may be influenced by lifetime exposure, probably at very low levels, to environmental toxicants," she says. Exposure to these chemicals is a consequence of living in the modern world and McLaughlin says little can be done to reduce women's susceptibility. But the research underpins the importance of her work in trying to extend the life of healthy oocytes and improve outcomes for couples trying to conceive later in life. Professor Eileen McLaughlin researches in collaboration with the Hunter Medical Research Institute's (HMRI) Pregnancy and Reproduction Program. HMRI is a partnership between the University, Hunter New England Local Health District and the community.
Born in 1955
March 1979: Graduated in Biological Science in the University of Florence with 110/110 cum laude.
1979-1984: post-doctoral fellowship in the Institute of Clinical Pharmacology of the University of Florence.
April-May 1980: visiting scientist in the Laboratory of Biochemistry of the Imperial College of Science and Tachnology (London), directed by Dr. J. Hughes after winning a Wellcome Research Travel Grant for two months. During this visit she learns methods of biological assays.
November 1981: win a grant from Italian National Research Council (CNR Rome) for three years.
March-April 1982: visiting fellow in the Laboratory of preclinical Pharmacology of the National Institute of Health (Washington, USA) directed by Prof. E. Costa to learn HPLC techniques.
November 1982: admitted to the post-graduate course in pharmacology at the University of Milan (Prof. F. Berti)
November 1984: Specialized in Pharmacology at the University of Milan (70/70).
1984: The Grant from CNR is renewed. She become intern in the Laboratory of Endocrinology of the University of Florence directed by Prof. M. Serio.
1988-1990: two years research fellowship in the Laboratory of Nephrology directed by Prof. M. Dunn at Case Western Reserve University (Cleveland, Ohio).
July 1990-2001: Researcher in the Andrology Unit of the University of Florence directed by prof. G. Forti.
January 2002: win a position of Researcher in the University of Florence.
May 2005 - Present : Associate Professor in Clinical Pathology (MED/05)
Fariba Mohtashami completed her medical degree, specialist training and residency in Obstetrics and Gynecology in 1997 before immigrating to Canada in 2002. At the University of British Columbia (UBC), Vancouver, she gained her Canadian credentials after a 5-year residency, which she completed in 2009. At the completion of OB/GYN residency she received the “Laparoscopy Award”, presented to the Chief Resident exhibiting the best proficiency in minimally invasive gynecologic surgery. With a keen interest in advanced laparoscopic (keyhole) and hysteroscopic surgery Dr. Mohtashami received further advanced surgical training at the University of Saskatchewan, 2011-2012 where she completed an official Fellowship in Minimally Invasive Gynecologic Surgery to achieve her professional goal of being an advanced pelvic surgeon.
Gerald P. Schatten, PhD
Professor Gerald Schatten is Director of the Pittsburgh Development Center, Professor of Obstetrics, Gynecology and Reproductive Sciences, Cell Biology, Bioengineering and Director of the Division of Developmental and Regenerative Medicine. Dr. Schatten has directly trained >50 doctoral and postdoctoral fellows, along with several MD, MD-PhD, and DVM trainees. He is active in advanced research training and was the founding director of the FRONTIERS IN REPRODUCTION, the premier reproduction training vehicle for MD and PhDs. Dr. Schatten is currently President of UNESCO’s International Cell Research Organization. With extensive funding from the National Institutes of Health. Dr. Schatten is the recipient of an NIH MERIT, and earlier a Research Career Development Award, was honored by the Czech Academy of Sciences with their Purkinje Medal of Science, elected as a Delegate of the American Association for the Advancement of Sciences, a Mentor Awardee of the American Society for Cell Biology, Elected Australian Society for Reproductive Biology President’s Lecturer, awarded the Daniel Mazia Award from Stanford University, and a Doctor HonorisCausa (Honorary Doctorate) from the University of Nova Gorica, presented by the President of the Republic of Slovenia, among other honors. His > 300 papers on stem cells, regeneration, fertilization, cell biology, development, infertility, assisted reproductive technologies, as well as strategies for rectifying past injustices in scientific careers, have appeared in premier journals including Nature and Science. Dr. Schatten is also an eloquent advocate for research in reproduction, development, regeneration and stem cells.
Gil Mor, M.D., Ph.D. is Professor of Obstetrics and Gynecology and Reproductive Science at Yale University School of Medicine. Dr. Mor has focused his studies on the interaction between reproductive organs and the innate immune system. In his research he examines topics related to the immunology of implantation, the role of apoptosis in tissue remodeling and cancer, as well as the role of inflammation in cancer formation and progression. Dr. Mor earned his Ph.D. in Immunoendocrinology from the Weizmann Institute of Science and his M.S. and M.D. from Hebrew University in Jerusalem.
He completed postgraduate training at the National Institutes of Health where he worked in the Laboratory of Immunology as a Postdoctoral Fellow. At Yale University, he serves as Director of the Reproductive Immunology Unit and the Translational Research Program, “Discovery To Cure” (DTC). The Reproductive Immunology Unit has made important contributions in our understanding of the immunology of the female reproductive tract in normal and abnormal conditions. His studies on apoptosis and cancer, primarily the role of the Fas/FasL system in tissue renewal and the regulation of apoptosis in cancer cells and immune cells, have been published in prestigious journals and are highly cited.
Further, Dr. Mor’s studies on the regulatory pathways controlling cell survival and apoptosis in ovarian cancer cells led to the characterization of a new compound, phenoxodiol, which was used as a chemosensitizer based on its capacity to reactivate the apoptotic cascade. In 2005, Dr. Mor’s laboratory developed and characterized a new test for the early detection of ovarian cancer. The test evaluated likelihood of developing ovarian cancer among high risk populations. This test has been licensed to several companies in the USA, China, Europe and Israel.
More recently, Dr. Mor’s laboratory identified a unique population of ovarian cancer cells with characteristics of stem cells. These findings have opened a new area of research which may help to understand the source of recurrence and chemoresistance. Dr. Mor has more than 250 publications and is the editor of three books on “Immunology of pregnancy” and “Apoptosis and Cancer”.Dr. Mor is recipient of several national and international prizes, including the J. Christian Herr Award-from the Society for Reproductive Immunology.
He is member of the American Association for Cancer Research and the Society for Gynecologic Investigation and the former Treasurer of the American Society of Reproductive Immunology. He is also honorary member of several scientific societies in South America, China and Japan. Dr. Mor was elected as the Editor in Chief of the Journal of the American Society for Reproductive Immunology and is the member of the Editorial Board of numerous journals. Dr. Mor has five patents licensed to pharmaceutical companies. Dr. Mor is also founder and organizer of the DTC High School internship program; an educational program to promote science in high school students, undergraduate students, and science educators. The program is an internationally recognized educational activity, enrolling 30 students out of more than 200 applications per year. The program is supported by NIH/NCI and private foundations.
Biostatistician, currently based at the Centre for Biostatistics at University of Manchester. his PhD looked at methods to analyse complex sequential data in IVF. During my MSc Statistics, He was told that he did not even 'understand what statistics was' and that my 'writting could be improved'. Hopefully He now have at least some idea what statistics is and have managed to improve my writting to a reasonable level. Interested in finding collaborators who, recognising the implications of research for patients, would like to do good quality work.
Jacques Cohen is an experienced embryologist and laboratory director. He is the Director of The Art Institute of Washington. Jacques Cohen is one of the founders of Reprogenetics, an independent PGD service based in the USA and director of Tyho-Galileo Research Laboratories – an organization that promotes and conducts human fertilization and preimplantation research. He is also the Scientific Director of IVF-Online. He was trained in the 1970s at Erasmus University in Rotterdam, Holland as a Reproductive Scientist specialized in in vitro fertilization and cryobiology. He was an embryologist at Bourn Hall Clinic, the world’s first IVF clinic directed by Robert G. Edwards (Nobel Prize in Medicine in 2010) and moved to the USA in 1985. He has authored more than 200 publications and several textbooks. He has developed several techniques used in IVF laboratories. He is the senior editor of Reproductive Biomedicine Online and the North-American editor of Zygote. He was the founder of Alpha – Scientists in Reproductive Medicine and one of the founders of the Preimplantation Genetics Diagnosis International Society (PGDIS). He is associated with several laboratories involved in IVF and PGD both in Europe and the USA. His interests are embryonic viability, cryopreservation and developing tests and tools for IVF laboratories.
Corporate Lab Director
Dr. Swain is the laboratory director of CCRM. He is board certified as a High-Complexity Clinical Laboratory Director and responsible for oversight of laboratory operations. Dr. Swain obtained his BSc from Hillsdale College in his native Michigan, his MSc in Animal Science from Purdue University and his PhD Molecular and Integrative Physiology from the University of Michigan. Dr. Swain is also actively involved in research focused on improvement of in vitro culture conditions. Studies range from very basic in nature to translational research aimed at improving existing means of treating infertility.
Jason E. Swain, PhD, HCLD is the Corporate Laboratory Director of the CCRM IVF Laboratory Network, overseeing a growing network of 10 clinical IVF laboratories in North America. Dr. Swain is responsible for laboratory design, protocol/procedure implementation, as well as staff training and ongoing quality control monitoring for the network embryology, andrology and endocrinology laboratories. He is also an Adjunct Clinical Associate Professor in Obstetrics and Gynecology at Rutgers University as well as at the University of Minnesota. Jason completed his BSc at Hillsdale College in his native Michigan, his MSc in Animal Science at Purdue University, his PhD in Molecular & Integrative Physiology at the University of Michigan. Dr. Swain has published more than 38 peer‐reviewed articles, authored several book chapters and contributed to various other publications within the field of assisted reproduction. His primary research interests include pursuit of methods to improve in vitro embryo culture conditions through reduction of environmental stressors via modification of both the physical and chemical culture environment. Dr. Swain has given numerous regional, national and international invited lectures on various topics related to the IVF laboratory. He is the Editor‐in‐Chief of the Journal for Clinical Embryology, Associate Editor for the Journal of Assisted Reproduction and Genetics, sits on the editorial board for 6 journals and acts an ad hoc reviewer for 19 others.
His overall research interest is the impact of the micro-environment surrounding oocytes and embryos, especially nutritional factors, within both the in vivo (follicular/oviduct/uterine) and in vitro environment. This encompasses the following research:
Hypoxia, Hypoxia inducible factors and their role in reproduction
His laboratory has had a long standing interest in the role of oxygen concentration in regulating events within the female reproductive tract. This is primarily because both oocytes (within follicles) and pre-implantation stage embryos (especially within the uterus) develop in what is normally considered low oxygen concentration environments. We have focussed on the role of the transcription factor, Hypoxia Inducible Factor, in regulating a number of transitional events, such as follicle antrum formation, corpus luteum formation, early embryo development and implantation.
Glucose concentration, the hexosamine biosynthesis pathway and oocyte competence.
His laboratory has been investigating the less well-recognized pathway of glucose metabolism, the hexosamine biosynthesis pathway and its relationship between oocyte and early embryo competence. My laboratory has found that in both oocytes and embryos are sensitive to increased hyperglycemia through the O-linked-β-glycosylation of intracellular proteins. This has relevance to the negative impact that diabetes is known to have on reproductive health.
Oocyte secreted factors and oocyte competence.
With my collaborators, my laboratory has been studying cumulus cell – oocyte interactions and the role of oocyte secreted factors (OSFs). This has led to the discovery that the addition of native OSFs or the addition of recombinant specific factors, growth differentiation factor-9 (GDF-9) or bone morphogenetic protein-15 (BMP-15) to in vitro maturation of cattle or mouse oocytes significantly increases subsequent embryo yield by 50% and improves quality of resultant embryos and increases implantation rates post-transfer. This discovery is now patented and licensed to Cook Medical. We are pursuing this research area further and our aim is to apply this discovery to clinical IVM.
“The Spark of Life”
Within the ARC Centre for NanoscaleBioPhotonics, I lead a theme that examines the application of photonics and fluorescence sensing technologies to early developmental events, in particular oocyte maturation and fertilization. The aim here is to measure critical events in early development in real-time and in situ, and to develop new devices that can be used to measure reproductive health within one's own home.
Dr. Conaghan has over two decades of experience in human embryology and is best known for his studies on embryo culture and metabolism. He trained in Embryology and Andrology at the Hammersmith Hospital in London and graduated with a PhD in human embryology from the Royal Postgraduate Medical School at the University of London in 1994. He’s a Board-Certified High-complexity Clinical Laboratory Director in the disciplines of Embryology and Andrology. In 1995, Dr. Conaghan was recruited by the UCSF IVF Program as their Clinical Laboratory Director. He later moved to Pacific Fertility Center in San Francisco where he has been the director since 1999. He is a strong advocate for elective single embryo transfer (eSET) in IVF, and therefore for high standards for culturing and vitrifying embryos. Dr. Conaghan ensures the highest quality of patient care with state-of-the-art-facilities and an experienced team of embryologists and is committed to continuing education for IVF lab professionals. He lives in Half Moon Bay with his wife and 3 children.
Conaghan J, Chen AA, Willman SP, Ivani K, Chenette PE, Boostanfar R, Baker VL, Adamson GD, Abusief ME, Gvakharia M, Loewke KE, Shen S., Improving embryo selection using a computer-automated time-lapse image analysis test plus day 3 morphology: results from a prospective multicenter trial., FertilSteril. (2013) 100(2):412-419
Iager AE, Kocabas AM, Otu HH, Ruppel P, Langerveld A, Schnarr P, Suarez M, Jarrett JC, Conaghan J, Rosa GJ, Fernández E, Rawlins RG, Cibelli JB, Crosby JA., Identification of a novel gene set in human cumulus cells predictive of an oocyte's pregnancy potential., FertilSteril. 2013 Mar 1;99(3):745-752
Racowsky C, Vernon M, Mayer J, Ball GD, Behr B, Pomeroy KO, Wininger D, Gibbons W, Conaghan J, Stern JE. Standardization of grading embryo morphology. FertilSteril (2010) 94:1152-3.
Pomeroy KO, Harris S, Conaghan J, Papadakis M, Centola G, Basuray R, Battaglia D. Storage of cryopreserved reproductive tissues: evidence that cross-contamination of infectious agents is a negligible risk. FertilSteril (2010) 94:1181-8.
The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting, Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology; BasakBalaban; Daniel Brison; Gloria Calderon; James Catt;
Molecular biologist AtiGenomix S.L., Valencia, Spain
Dates: Employed May 2014 – Present
Laboratory Manager at Igenomix Kuwait.
Previously, Laboratory Manager at Igenomix Mexico, supervisor of the ERA (Endometrial Receptivity Analysis) laboratory at Igenomix Headquarters (February 2016 - May 2017) and researcher at the Department of Women's and Children's Health at KarolinskaInstitutet (Stockholm, Sweden) on biomarkers of endometrial receptivity (May 2015 - February 2016)
Technical Specialist - Public Health at VAERSA S.L. Valencia, España
Dates: Employed Mar 2011 – Feb 2013
Supervisor of the Department of Environmental Health at Public Health Center of Denia (Alicante, Spain) for Conselleria de Sanitat (Valencian Regional Government).
Development and implementation of systems of quality management and occupational health.
Research in Public Health focused on legionnaire’s disease.
Field Biologist at FomentoAgrícolaCastellonense, S.A. (FACSA). Castellón, España
Dates: Employed Jul 2000 – Jan 2011
Head of operations, including management of natural areas, surveillance and control of discharges and sewage treatment stations, water analysis, prevention of occupational hazards, inspection of industrial facilities, personnel management, development and implementation of quality management and geographic information systems.Research in environmental biology focused on water contaminants and their affection on sewage disposal.
University of Valencia
Degree Name PhD Student
Field Of Study Reproductive medicine
Dates attended or expected graduation 2016 – 2021
• UniversitatOberta de Catalunya
Degree Name Master’s degree in occupational health
Field Of Study Technical specialist in occupational health
Dates attended or expected graduation 2011 – 2014
Activities and Societies: Occupational Risk Prevention in Work Safety, Industrial Hygiene and Ergonomics.
Occupational Risk Prevention in Work Safety, Industrial Hygiene and Ergonomics.
Awarded Best Master's Thesis on "Comprehensive study of occupational health at the Public Health Center of Denia (Alicante)".
• Universidad Internacional Menéndez Pelayo
Degree Name Master’s degree
Field Of Study Environmental health
Dates attended or expected graduation 1999 – 2000
Activities and Societies: Waste management, environmental diagnosis, natural hazards, public health, natural resource management, environmental quality systems, legal aspects of the environment, and research in environmental health.
• University of Valencia
Degree Name Licentiate degree
Field Of Study Biology
Dates attended or expected graduation 1994 – 1999
Activities and Societies: Genetics, microbiology, ecology.
Prior to joining the Centre for Cancer Research, Professor St. John was the Head of the Centre for Genetic Diseases at Hudson Institute, after having been recruited from the University of Warwick in the UK where he held the position of Professor of Reproductive Biology.
After completing his degree in Physiology at the University of Sheffield in 1995, Prof St. John completed his PhD entitled ‘The role of mitochondria in male fertility’ at the University of Birmingham. In 2000, Prof St. John was appointed as a lecturer in Mitochondrial and Reproductive Genetics at the University of Birmingham. Along with running his research program, he provided undergraduate and postgraduate teaching and supervision and was the divisional coordinator for graduate studies.
From March 2000 until January 2001, Prof St. John undertook a Sabbatical as a Mellon Fellow at Professor Gerald Schatten’s laboratory at Oregon National Primate Research Center in the USA. Prof St John was also awarded an Endeavour Fellowship in 2007 to undertake research work at Monash Institute of Medical Research (now Hudson Institute). This allowed him to familiarise himself with the Institute and its research and establish some of his program in Australia.
Prof St. John has numerous publications in international journals, including The Lancet, Nature Chemical Biology, Nature Cell Biology, Nucleic Acids Research, Cell Death & Differentiation, Stem Cells, Development, Journal of Cell Science and Genetics. Prof St. John also reviews submissions for a number of journals and grant-awarding bodies and is Reviews Editor for Molecular Human Reproduction. In the UK, he advised Government, Parliament and the Royal College of Obstetricians and Gynaecologists on policy related to stem cells and reproduction. He also advised the Human Fertilisation and Embryology Authority on stem cells and embryo policy, and reviewed licence applications. In 2013, he received the Society for Reproductive Biology’s Award for Excellence in Reproductive Biology.
The overall aim of Prof St. John’s research is to understand how the nuclear and mitochondrial genomes interact during development in order that cells, tissues and organs function efficiently. He is applying this knowledge to develop reproductive strategies for women that suffer from repeated failed fertilisation outcome or embryo developmental arrest; and enhanced genetics for animal breeding purposes. He also focuses on the role of mitochondrial DNA in tumour formation.
Prof St. John’s current research focuses on developing and using stem cell, tumour-initiating cell and large animal models to define key mitochondrial DNA replication events during development and how they influence reproductive and developmental outcomes; and how mitochondrial DNA copy number can be modulated to prevent tumours from forming.
Keith Isaacson was born and raised in Atlanta, Georgia. He graduated cum laude from Tulane University with honors in biology in 1979 and attended medical school at the Medical College of Georgia. Dr. Isaacson finished his residency in Obstetrics and Gynecology at the Ochsner Clinic in New Orleans, LA. He then finished a fellowship in Reproductive Endocrinology and Infertility at the University of Pennsylvania. He is currently board certified in Reproductive Endocrinology and general Obstetrics and Gynecology.
Dr. Isaacson was the Division Director of Reproductive Endocrinology and Infertility at the Massachusetts General Hospital from 1991 until 2001. In the fall of 2001, he left to open a center for minimally invasive gynecologic surgery and infertility at Newton Wellesley Hospital. He is currently director of the residency and fellowship for minimally invasive gynecologic surgery and infertility. Dr Isaacson is the Co-Director of the Center for Gynepathology Research at the Massachusetts Institute of Technology.
Dr. Isaacson is the immediate past president of the Society of Reproductive Surgeons (SRS) and the past president of the American Association of Gynecologic Surgeons (AAGL). He is currently the President of the AAGL/SRS Fellowship Board of Directors and on the Board of Directors of the Society of Laparoscopic Surgeons. His recent awards include the Distinguished Surgeon Award from the American Society of Reproductive Medicine in 2013. Dr. Isaacson has focused his clinical career in advance hysteroscopic and laparoscopic procedures in women wishing to maintain their reproductive potential. He has over 75 peer reviewed publications, numerous textbook chapters and had edited two textbooks on laparoscopic and hysteroscopic surgery.
Dr. Keith Isaacson
Keith Isaacson, MD
Director of Minimally Invasive Gynecologic Surgery and Infertility
Newton Wellesley Hospital
Associate Professor of Obstetrics and Gynecology
Harvard Medical School
MIGS Center 2W
Newton Wellesley Hospital
2007 MD. Aarhus University
1999 Upper secondary school-leaving examination
April 2015-present Post doc, Dep of Clinical Biochemistry/Clinical Institute, Aarhus University Hospital
Oct 2014-march 2015 Medical Doctor, Dep of Clinical Biochemistry, Aarhus University Hospital
April 2013- sept. 2013 Post.doc. Fertility Clinic/Clinical Institute, Aarhus University
Jan 2010 - marts 2013 PhD scholar Aarhus University
Nov. 2009 – dec. 2009 Research assistant, Fertility Clinic/Clinical Institute, Aarhus University
June 2007 – okt. 2009 Internship, Region Midt, Randers (Medicine, Surgery, General Practice)
Aug. 2003- juli 2004 Pre-graduate scholarship at Institute of Medical Biochemistry, Aarhus University
May 2005-Feb 2006 Maternity Leave
July 2008 - March 2008 Maternity leave
Awards and nominations
Awarded a SapereAude post doc grant from the Danish Council for Independent Research, Ministry of Higher Education 2014. Awarded the Aarhus University Research Foundation (AUFF) PhD prize 2014, Winner of the Fogh-Nielsen prize competition (Awarded for excellent achievements in PhD research), Health, Aarhus University 2013, shortlisted for best abstract at ESHRE (European Society of Human Reproduction and Embryology) 27th, 28th, 29th and 30th annual meeting (first author), Nordic InfuCare Research Grant 2012
Academic degrees and Scientific production
PhD from Aarhus University based on the dissertation “Human embryo development and viability assessed by time-lapse imaging”. 1st author of 11 papers, co-author of five and last author of two papers published in international peer-reviewed journals. Author of two book chapters (one in press). H-index 9 (Scopus).
Associate Editor for Human Reproduction. Reviewer for several international journals including Human Reproduction and Fertility and Sterility. Certified among the top 10% of the reviewers in Human Reproduction 2013. Several oral presentations (peer reviewed abstracts) at international meetings including ESHRE and ASRM.
Invited speaker at the Alpha Scientist in Reproductive Medicine biannual meeting (2016), American Society of Reproductive Medicine (ASRM) annual meeting (2015), In Vitro Fertilization and embryo transfer, organized by the office of continued medical education, UCLA School of Medicine (2015), Il centro de medicinadellariproductione, Catania (2015), ISIVF, 18th World IVF Congress of In Vitro Fertilization (2015) (company symposium), Nordic IVF-Laboratory Society 2015, Nordic Fertility Innnovation, Stockholm (2014), ESHRE 30th annual meeting pre-congress course, 5th DVR congress, (2013) 25th annual Meeting Belgian Society for Reproductive Medicine (2012), Fertilitech Company Symposium, ESHRE 26th annual meeting (2011)
Member of the evaluation committee for R&D in Estonia, appointed by the Estonian research Council 2015. Member of the Organizing Committee PhD day 2016, Aarhus University, Coordinator of medical education, KBA AUH (2014), Organiser of workshops at the 6th and 7th ORPHEUS meeting (Organization for PhD education in Biomedicine and Health Sciences in the European System), Vice chair and member of FP Forum Aarhus University (2012) Board member of the PhD Association, Health, AU (2010-2012), Member of the PhD-council, Health, AU (2011), Member of the planning committee for 3rd Annual Meeting Translational Medicine AU (2011).
After a Master’s degree in Biology in 1996 at the University of Bologna, Italy, LodovicoParmegiani completed his postgraduate specialization (PhD) in Biochemistry and Clinical Chemistry in 2000 at the University of Modena and Reggio Emilia, Italy. In 2008 he received certification as Senior Clinical Embryologist from the European Society for Human Reproduction & Embryology (ESHRE). In his career he has developed and optimized devices and methods for clinical embryology and has published almost one hundred papers and book chapters in this field. His current research interests are cryobiology, gamete selection and micromanipulation. He is editor for many international scientific journals. He is member of the Executive Committee and the Scientific Director of Italian Embryology Society (SIERR). Lodo is a highly sought embryologist specialized in tutoring for handson workshops and he has organized
and chaired many congresses, symposia, and workshops. Furthermore, he is consultant for IVF lab design, equipment and management. In addition, he is currently advisor for companies in the IVF field. He holds an international patent for: ”device and method for sterilizing liquid nitrogen by ultraviolet radiation”. He is currently the Laboratory Director at the Reproductive Medicine Unit, GynePro Medical Centers in Bologna, Italy.
Areas of Expertise
Vitrification, Cryobiology, Liquid Nitrogen sterilization, ICSI, IMSI, PICSI, sperm selection, hyaluronic acid
Professor of Development and Stem Cell Biology at University of Cambridge. Trying to build life from stem cells to understand it better.
is a Polish/British developmental biologist. She is Professor of Mammalian Development and Stem Cell Biology in the Department of Physiology, Development and Neuroscience and Fellow of Sidney Sussex College at the University of Cambridge
Zernicka-Goetz was born in Warsaw, Poland. She received her Master of Science degree (summa cum laude) in developmental biology (1988) and her PhD degree in the developmental biology of mammals (1993) from the University of Warsaw with one year (1990–91) spent at the University of Oxford.
Career and research
After obtaining her Ph.D., Zernicka-Goetz spent two years as a post-doctoral EMBO fellow with Professor Sir Martin Evans in the Wellcome Trust / Cancer Research UK Institute (now the Gurdon Institute) in Cambridge. In 1997, she started her independent group in the Gurdon Institute where she was a Lister Institute Senior Research Fellow (1997-2002) and subsequently a Wellcome Trust Senior Research Fellow. In 2014, she moved her laboratory to the Department of Physiology, Development and Neuroscience of the University of Cambridge. In 2007, she was awarded a readership and in 2010 a professorship at the University of Cambridge. She was elected a member of the European Molecular Biology Organisation in 2007, a fellow of the British Academy of Medical Sciences, 2013, and a foreign member of Polish Academy of Arts and Sciences in 2016.
Zernicka-Goetz carried out her Ph.D. studies with AndrzejTarkowski (Warsaw) and Chris Graham (Oxford) and her post-doctoral training with Sir Martin Evans (Cambridge). Upon setting up her independent group in 1997, she studied the mechanisms regulating early mammalian development. To do this, she was first to establish RNA interference in mammalian cells to determine cell fate in the mouse embryos.At that time, she also began to trace the origins and destinies of cells in the preimplantation mouse embryo that let her to discover that cell fate specification begins earlier than expected, an unexpected discovery but subsequently validated by her group and others. She found that this development of cell identity begins with heterogeneity in epigenetic regulation at the 4-cell stage that directs a molecular cascade establishing cell polarity, position and fate.
Her recent development of systems permitting both mouse and human embryogenesis during implantation and early post-implantation stages in vitro allowed her to reveal that mouse and human embryo remodelling at implantation is done autonomously by the embryo. She uncovered the mechanism underlying embryo remodelling between the blastocyst and gastrula stages that has led to a change in the textbook model. Her demonstration of the self-organisation of human embryos developing in vitro until day 13/14, gastrulation, has provided an unprecedented opportunity to study human development at previously inaccessible and critical stages. This discovery was hailed as the people’s choice for the scientific breakthrough of 2016 by Science magazine. The knowledge she gained through her work on how the embryo develops during the blastocyst to gastrula transition, allowed her to mimic these developmental processes with different types of stem cells in vitro. This led her to the pioneering success of constructing embryo-like structures from pluripotent embryonic and multipotent extra-embryonic (trophoblast) stem cells in a 3D scaffold of extra-cellular matrix proteins in vitro.These "synthetic embryos" recapitulate the natural architecture of the embryo and their patterns of gene expression leading to the specification of the germ layers and germ cells. This system allowed her to identify signallingpathways responsible for morphogenesis of stem cells into embryos. Together these models bring outstanding potential for understanding development and for regenerative medicine.
Translational studies: Zernicka-Goetz's work brings insight of great value to the IVF clinic. Her group have shown that sperm entry induces actomyosin-driven cytoplasmic flows that are predictive of successful development to birth in the mouse. This provides an opportunity to identify quantitatively and non-invasively the healthiest embryos to transfer to would-be-mothers in IVF.
Stimulated by the finding of placental cells with abnormal chromosome complements (aneuploid cells) in her own pregnancy, she began to study the consequence of aneuploidy upon development in a mouse model. Her lab generated an experimental model to find that aneuploid cells arising during embryogenesis in the mouse embryo become eliminated by apoptosis in embryonic but not extra-embryonic tissues. This gives insight into why mosaic aneuploidy identified by chorionic-villus-sampling can be tolerated in human pregnancies.
Through public engagement the potential impact of Zernicka-Goetz's work is now becoming widely recognised.
Awards and honors
• International Foundation IVI Award for the Best Basic Research in Reproductive Medicine, 2017
• Foreign Member of Polish Academy of Arts and Sciences, elected 2016
• Winner of the People’s Vote for Scientific Breakthrough of the year 2016 by Science magazine
• Fellow of British Academy of Medical Science, elected 2013
• Anne McLaren Memorial Lecture Award, International Society of Differentiation, 2008
• Member of European Molecular Biology Organisation, elected 2007
• Young Investigator Award, EMBO (2001-2004)
• Wellcome Trust Senior Research Fellowship (2002-2008, 2008-2013, 2013–2018)
• Lister Institute of Preventative Medicine Senior Research Fellowship (1997-2002)
• EMBO Long-term Fellowship for post-doctoral studies at the University of Cambridge (1995-1997)
• Best Ph.D. thesis Award, Polish Ministry of Education, 1994
• Promising Young Scientist Prize, Foundation for Polish Science, 1993
IVF Scientist Supervisor
Speciality: IVF Laboratory
IVI Clinic Valencia
Training: Graduated in Biological Sciences.
FPI scholarship from the Conselleríad'EducacióiCiencia, Department of Obstetrics and Gynaecology, Faculty of Medicine from the University of Valencia. Pre-doctorate fellowship at St. Mary's Hospital, Manchester University. Doctor "cum laude" in Biological Sciences. European Doctor Degree from the University of Valencia. Master's Degree in Research Methods: Design and Statistics, Universidad Autónoma de Barcelona.
Care activity:Co-director of the Andrology Lab at IVI Valencia (2000-2004)
Teaching activity:Head Professor of the Master's Degree in Biotechnology of Reproduction, University of Valencia.
Awards and merits:American Society of Reproduction Award (1999). Three Awards from the American Society of Andrology (2007, 2009 and 2011). Two Awards from the Spanish Fertility Society (SEF) (2000 and 2001). One international patent.
Research and scientific activity:
Áreas de embriología e infertilidadmasculina. Publicaciones: 81 artículos en revistasinternacionales y 40 artículos de libros, 225 comunicaciones a congresosinternacionales. Trestesisdoctoralesdirigidas y actualmentedirección de 8 doctorandosdelprograma de Biotecnología, Facultad de Biología.
1- Marta Shahbazi is an Associate Faculty Member who works with Magdalena Zernicka-Goetz to evaluate the literature relevant to their research interests.
Marta completed her BSs in Biology and MSs in Molecular Biomedicine at the University Autonoma of Madrid. She did her PhD at the Spanish National Cancer Research Centre (CNIO) under the supervision of Dr Mirna Perez-Moreno, working on microtubule binding proteins that regulate cell-cell adhesion in the epidermis.
Marta joined Magda's group in 2014 to work on tissue patterning in postimplantation mouse development.
The development of an embryo takes place through a series of cell fate decisions and morphogenetic movements. Cell lineage specification events progressively restrict cellular fates, from the pluripotent cells of the early embryo to the highly differentiated cell types found in the adult organism. On the other hand, collective cellular movements shape tissues and sculpt the future body. Alterations in these processes result in embryo lethality or congenital malformations.
Despite great advances on understanding the genetic basis of cell fate decisions, how these genetic changes are coordinated at the tissue level to drive the morphogenesis of the embryo is still a mystery.
My current research focuses on understanding how changes in tissue architecture are coordinated with a progressive restriction of development potential during early mouse and human embryo development.
Mary Sabatini is an obstetrician-gynecologist in Boston, Massachusetts and is affiliated with multiple hospitals in the area, including Massachusetts General Hospital and North Shore Medical Center. She received her medical degree from Columbia University College of Physicians & Surgeons and has been in practice between 11-20 years. She is one of 147 doctors at Massachusetts General Hospital and one of 47 at North Shore Medical Center who specialize in Obstetrics & Gynecology.
Dr. Matthew David (Tex) VerMilyea was born in Laredo, Texas and graduated 3rd of his class from United High School. He obtained early acceptance into Cornell University in Ithaca, New York where he played football and pole-vaulted. His interests in reproductive physiology began during his undergraduate studies at Cornell, where he obtained a Bachelor of Science degree in Animal Science, Cum Laude with Distinction in Research.
From his early experiences in the theriogenology laboratories at Cornell, Tex quickly found his forte in embryology and has since gained various experiences from around the world. Tex received his PhD in Epigenetics from The University of Birmingham in the United Kingdom. He then continued his professional preparation by completing post-doctoral fellowships in the chromatin and gene expression laboratories at the Institute of Biomedical Research in Birmingham, UK. He was later fortunate to be selected as a research fellow for the Japan Society for the Promotion of Science where he completed a second fellowship in the Laboratory of Mammalian Molecular Embryology at the RIKEN Institute in Kobe, Japan. Determined to maintain his foundation in genetic and molecular research, he chose to return to clinical human in-vitro fertilization (IVF) in order to hone his skills and develop a career as an accomplished embryologist. Upon his return to the United States, he was employed as an embryologist at Shady Grove Fertility in Maryland where he undertook intense training and soon became the lead Embryology Research Scientist and Senior Embryologist. At that time, Shady Grove was the largest full-service infertility service provider in North America.
Tex soon obtained Board Certification as a High Complexity Laboratory Director and Clinical Consultant from the American Board of Bioanalysis. Tex has previously served as the Director of Assisted Reproductive Technologies and Andrology Laboratories at Penn Fertility Care at the University of Pennsylvania in Philadelphia. He was appointed as an Instructor in the Division of Reproductive Endocrinology and Infertility at the Perelman School of Medicine at Penn.
Tex and his wife Lucy and 1-year-old daughter Hailey Rose recently relocated from Auckland, New Zealand where he served as the Scientific Director of Fertility Associates of New Zealand. He provided scientific guidance regarding the implementation of cutting-edge technologies and research throughout five IVF laboratories located in New Zealand and multiple clinics in Asia.
Tex is keen to now provide his experiences and expertise to patients seeing services as Texas Fertility Center and Ovation Fertility. Being a reputable leader in this ever-changing field of assisted reproduction, Tex continuously finds it rewarding when patients are successful at bringing home a healthy child.
Dr.Alikani started her work in the field of assisted reproduction in 1983 while she was completing her Master’s degree in developmental biology. Her long career includes appointments at The Center for Reproductive Medicine at Cornell University Medical Center-New York Hospital in New York, USA (1989 - 1995), and the Institute for Reproductive Medicine and Science at Saint Barnabas Medical Center in New Jersey, USA (1995 - 2004), where she worked alongside Dr. Jacques Cohen and the clinical teams to establish these laboratories as two of the leading laboratories in the United States. She completed her PhD studies in 2006 through Monash University’s External PhD program, under the mentorship of Professor Alan Trounson, and local supervision of Professor Steen Willadsen. Following graduation, she worked as a Senior Research Scientist (2006 – 2011) and undertook several novel research projects including derivation and cryopreservation of normal and abnormal human embryonic stem cells. Dr.Alikaniis currently an editor of Reproductive Biomedicine Online, holds positions as Laboratory Director as well as clinical consultant for ART laboratories in New York and New Jersey, USA, and serves on the Executive Board of Alpha Scientists in Reproductive Medicine. She has authored and co-authored more than 70 peer-reviewed articles and book chapters on the laboratory aspects of assisted reproduction and lectured extensively around the world on ART-related topics. Her research interests include division dynamics in mammalian eggs and embryos, fragmentation and other abnormalities of human embryo development in vitro, and improving IVF laboratory performance and IVF outcomes.
Dr. Bedaiwy is Professor and Division Head, Division of Reproductive Endocrinology & Infertility, UBC Department of Obstetrics and Gynaecology. Dr. Bedaiwy received his medical degree from Assiut University School of Medicine, Egypt where he graduated Valedictorian, summa cum laude.
Dr Bedaiwy completed: •Residency in Obstetrics and Gynecology at the University Hospital Case Medical Center, CWRU, Cleveland, Ohio, USA •Fellowship in Reproductive Endocrinology and Infertility at the University Hospital Case Medical Center, CWRU, Cleveland, Ohio, USA •Fellowship in Minimally Invasive Surgery at the Cleveland Clinic Foundation, Cleveland, Ohio, USA •Fellowship in Reproductive Endocrinology and Infertility in the Division of Reproductive Sciences, University of Toronto, Toronto, Canada •PhD from the University of Maastricht, the Netherlands for his work on ovarian tissue cryopreservation and transplantation Dr. Bedaiwy is a prolific author with over 200 publications, including 104 peer-reviewed publications. He is best known for his work in endometriosis, ovarian transplantation, in vitro fertilization (IVF) and minimally invasive surgery (MIS). His interests include IVF, MIS, robotic surgery, fertility preservation in cancer patients, and endometriosis. He is also the Associate Editor of the Human Reproduction Journal which is the official journal of the European Society of Human Reproduction and Embryology (ESHRE). Dr. Bedaiwy has had a career-long interest in high quality medical care, research and education. His research interests include IVF, MIS, robotic surgery, fertility preservation in cancer patients, and endometriosis.
Specialist in Endocrinology EAA Certified Androlog and PhD, Department of Growth and Reproduction, Juliane Marie Center
Male infertility; impaired semen quality; testosterone deficiency; gynaecomastia; idiopathic hypogonadotropichypogonadism; Congenital Adrenal Hyperplasia; Klinefelter Syndrome
Main research areas
Since 1996 NielsJørgensen has undertaken and coordinated Danish and international scientific projects focussing on the testicular function of more than 12,000 men from the general populations, selected fertile or infertile men. ). Besides describing the acutal testicular function (semen quality and endocrine function) these studies have also focussed on addressing the impact of exogenous exposures, life style and genetic factors on testicular function.
Impact of life style, genetic factors and exogenous exposures on testicular function.
Long term concequences of impaired testicular function
Methods for assessment of semen quality.
Treatments of male infertility.
When it comes to treating fertility patients, Dr. Pasquale Patrizio believes, “you have to be a good listener.” As Director of the Yale Fertility Center and the Fertility Preservation Program, he works closely with each patient to develop a comprehensive plan that addresses his or her specific hopes and goals.
In November 2014, Dr. Patrizio was presented with the Hope Award for Advocacy by RESOLVE, The National Infertility Association. Dr. Patrizio, who is also a professor in the Ob/Gyn department at Yale School of Medicine, shares this award with his collaborator Josephine Johnston, a research scholar and director of research at The Hastings Center. The pair was honored by RESOLVE for their work to reduce risks associated with in vitro fertilization (IVF) and to increase patient access to infertility treatments.
Patrizio received his medical degree at the University of Naples in Italy and his Master of Science in Bioethics at the University of Pennsylvania. He completed his residency in Ob/Gyn-Reproductive Endocrinology at the University of Naples and a second residency in Andrology-Male Reproduction at the University of Pisa in Pisa, Italy. Back in the United States, he completed a residency in Obstetrics and Gynecology and a fellowship in Reproductive Endocrinology and Infertility at the University of California, Irvine.
While treatment of infertility (for both men and women) is his primary clinical interest, Dr. Patrizio also focuses on IVF/ICSI, egg donation, gestational surrogacy and preservation of fertility in cancer patients. Among his many research interests are whole ovary cryopreservation, oocyte (egg) freezing, methods to assess egg and embryo competence and ethical issues in assisted reproduction.
Dr. Patrizio is board certified in Obstetrics and Gynecology, Reproductive Endocrinology and Infertility and Andrology. He has published more than 400 scientific papers and four books including an Atlas textbook for assisted reproduction. He has lectured worldwide on various areas of reproductive medicine. In 2013, he was recognized in the top 1% of reproductive endocrinologists in the United States.
Department of Urology and University of Pretoria Centre for Sustainable Malaria Control, University of Pretoria, Pretoria and Potchefstroom, South Africa
ACADEMIC QUALIFICATIONS OBTAINED
1973 MBChB on Medicine from University of Pretoria
1983 DSc on Physiology from University of Pretoria
1987 MD on Physiology from University of the Free State
WORK EXPERIENCE TODATE
1973 – Jan 1979: (Internship and then Medical/Senior Medical Officer in Surgery) - Provincial Administration of the Orange Free State: Voortrekker Memorial and Boitumelo Hospitals,Kroonstad
Febr 1979 - Dec 1984: Lecturer/senior lecturer and Senior/First Medical Officer Department of Urology, University of Pretoria, and Transvaal Hospital Services (TPA), HF Verwoerd Hospital (now Pretoria Academic Hospital)
Jan 1985 – June 1990:Head of Physiology – contract research.
Part-time Head Andrology Laboratory,Department of Urology - management ofand clinical research on male infertilityRoodeplaat Research Laboratories and clinical research on male infertility.
TPA,Medunsa and Ga-Rankuwa Hospital (now George Mukhari
Hospital).(Head of Physiology – contract research.
Part-time Head Andrology Laboratory, Department of Urology- management ofand clinical research on male infertility.
April 1988 – June 1990: “Part-time Head of Spermatology Laboratory
– management of and clinical research on male infertility” Department of Urology, University ofPretoria, and Transvaal Hospital Services (TPA), HF Verwoerd Hospital (now Pretoria Academic Hospital)
1 Apr 1991 – present:Part-time (sessions) Head of Andrology Laboratory – management of and clinical research on male infertility
July 1988 - present : Honorary Associate Professor, Dept. of Urology, Medunsa – Gauteng Provincial Government,
Department Health (formerly TPA) Ga-Rankuwa Hospital (now George Mukhari Hospital) and Medunsa (now University of Limpopo).
1 Apr 1991 – 2004: Part-time (sessions) Head of Spermatology Laboratory, Department of Urology – managementofandclinicalresearchonmale infertility
1996 –present: Appointed ExtraordinaryProfessor, Department of Urology, UP
(Gauteng Provincial Government, Department Health and the University of Pretoria)
Sept 2003 - June 2005: Part-time Physiology Professor, Department of Physiology
(University of Pretoria)
Jan 2005 – present:Senior Medical Officer, Department of Urology and Pretoria AcademicHospital (jointappointment)
(Department of Urology, University ofPretoria, and Gauteng Health Pretoria Academic Hospital)
July 2005 – 31 Dec 2006:Extraordinary lecturer, School of Health Systems and Public Health, UP
(University of Pretoria)
Sep 2008 – present:Chief Medical Officer and Lecturer, Department of Urology and Pretoria Academic Hospital (joint appointment)
(Department of Urology, University of Pretoria, and Gauteng Health Pretoria
Jan 2007-Dec 2010: Extraordinary Professor, School of Health Systems and Public Health, UP
University of Pretoria
2008 to present: Member of the Advisory Board
(Advisory Board: Men’s Health Forum)
International Society for the Study on the Aging Male (ISSAM) International Society of Environmental Epidemiology (ISEE)
Society of Environmental Toxicology and Chemistry (Europe) SETAC
African Branch of the Society of Environmental Toxicology and Chemistry (SETAC Africa) Urological Association of Southern Africa (UASA)
Professor Richard A Anderson MD, PhD, FRCOG, FRCPE first became involved in research in reproductive biology when undertaking an intercalated PhD as a medical student in the UK's Medical Research Council (MRC) Brain Metabolism Unit, on the role of the amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the hypothalamus and pituitary gland. Thereafter, he trained in obstetrics and gynaecology in Edinburgh, undertaking a two-year World Health Organisation (WHO) research fellowship in hormonal male contraception under the supervision of Fred Wu, at the MRC Reproductive Biology Unit. Then, he completed his training in reproductive medicine as a lecturer at the University of Edinburgh with David Baird, continuing research work in contraceptive development locally and in collaboration with colleagues in Nigeria, South Africa and Hong Kong.
After a year as a Travelling Fellow in the laboratory of Professor Sam Yen at University of California San Diego, he returned to a Consultant post at the MRC Research Biology Unit and at the Royal Infirmary of Edinburgh, with clinical work in infertility and reproductive endocrinology. He took up his present post as Professor of Clinical Reproductive Science at the University of Edinburgh in 2005, and has subsequently become head of the University Section of Obstetrics and Gynaecology. Over these years he established a research group focused mainly on the female reproductive lifespan, with laboratory work identifying mechanisms of development in the fetal ovary, and developing clinical research largely related to fertility preservation, with a particular interest in individualising the assessment of risk to fertility. This culminated in the first UK birth following ovarian tissue cryopreservation and transplantation.
His current research activity is predominantly in both clinical and laboratory studies in ovarian development and function after cancer, and in male contraception, continuing his links to WHO and to the National Institute of Child Health and Human Development (NICHD) in the US. Over the last decade, he has also been involved in the physiology and the development of clinical applications of the novel neuropeptides kisspeptin and neurokinin B. First-in-man studies with kisspeptin 10 demonstrated that this neuropeptide increased GnRH pulse frequency in normal men. More recent work using a neurokinin B antagonist has revealed physiological roles in both men and women, as well as potential therapeutic application in polycystic ovary syndrome (PCOS) and for menopausal hot flushes. He has published over 250 papers and has an H index of 66.
He has chaired the Royal College of Obstetricians and Gynaecologists (RCOG) Scientific Advisory Committee, and previously been a member of both that Committee and the Guidelines and Audit Committee. He has also been involved in RCOG working parties, producing reports on the reproductive effects of cancer treatment (jointly with the other UK Royal Colleges), and in fetal awareness. More recently, he was a member of the European Society of Human Reproduction and Embryology (ESHRE) Guideline Group on Premature Ovarian Insufficiency, he has contributed to guidelines produced by the Scottish Intercollegiate Guideline Network, and currently chairs a Scottish Government committee for the establishment of fertility preservation services. He is the founder coordinator of the new ESHRE Special Interest Group (SIG) in Fertility Preservation, and has previously been a deputy coordinator for the SIG in Reproductive Endocrinology. He has been a Visiting Professor in Adelaide, Copenhagen and Melbourne and continues active collaborations with colleagues in those cities and elsewhere.
He has served as an Associate Editor for three of the ESHRE human reproduction journals, for the Journal of Clinical Endocrinology and Metabolism, and for the Journal of Assisted Reproduction and Genetics. He is looking forward to the new challenges of being an Editor for RBM Online and seeing it develop further as a high choice journal for clinicians and scientists in reproductive medicine. Together with the rest of the Editorial team he hopes to contribute to make RBM Online a stand-out journal for novel and high-quality research in the field.
Assistant Professor and senior clinical embryologist at Academic Medical Center of the University of Amsterdam, An important focus of his research in past years has been Preimplantation Genetic Screening (PGS). In 2007, publication of his randomized controlled trial on PGS in the New England Journal of Medicine started a fiercely debated controversy on the use of PGS as it showed that the technique lowered pregnancy rates after IVF instead of increasing pregnancy rates.
Sarah Martins da Silva is a Consultant Gynaecologist and Obstetrician at Ninewells Hospital and Medical School's Assisted Conception Unit (part of NHS Tayside), which provides both NHS-funded and private fertillity treatment. She is also a Clinical Lecturer in Reproductive Medicine and an Honorary Senior Lecturer at the University of Dundee, where she teaches the Masters Programme in Human Clinical Embryology and Assisted Conception. She works on all aspects of subfertility investigation, and she runs an active programme of research focused on sperm biology and drug discovery for male subfertility. Previously, she studied at The University of Edinburgh and she was a Specialist Registrar in Obstetrics and Gynaecology at the Royal Infirmary of Edinburgh.
Sharon Mortimer PhD became a Clinical Embryologist in 1985, working at the Royal Women’s Hospital, Melbourne, Australia then the Foothills IVF Programme in Calgary, Canada. She then became a consultant in IVF as Director/Secretary of Mortimer Scientific Consulting Pty Ltd, and was Managing Director of GenARTech Pty Ltd, a laboratory supply company. She was the Laboratory Director at the Genesis Fertility Centre, the commissioning Scientific Director of the Pacific Centre for Reproductive Medicine, and is currently the Scientific Director of the Grace Fertility Centre in Vancouver. Since 2010, she has been a full-time consultant with Oozoa Biomedical Inc., in the areas of systems design and application in ART laboratories, and in research communications.
As a result of her personal experience with a complicated, high-order multiple pregnancy, she has promoted the concept of single embryo transfers since 1991 and her goal is for all IVF labs to have the competency to achieve this. She is the co-author of Quality and Risk Management in the IVF Laboratory, which has become a standard textbook in clinical embryology training, and has authored or co-authored over 40 peer-reviewed publications and book chapters and 100 conference presentations, and been an invited speaker at clinical and scientific conferences in North America, Europe, South Africa, the Middle East, and Australia. She is an active member of 10 professional societies, and was the Chair or co-Chair of the ART Lab SIG of the Canadian Fertility and Andrology Society (2002–2007), and was a member of their Professional Standards Sub-Committee which developed the certification standards for ART Lab professionals in Canada.
Sherman J. Silber is physician specializing in the field of infertility. He invented many of the infertility treatments in use today in the domain of IVF, sperm retrieval, ICSI, vasectomy reversal, tubal ligation reversal, egg and embryo freezing, ovary transplantation, and the reproductive biological clock.
He performed the world's first ovary and testicle transplants, created and popularized the microsurgical vasectomy reversal, and popularized ovarian tissue freezing to preserve female fertility. He was the first to research the genetic causes of infertility in men, and developed the TESE-ICSI technique for extracting sperm from men with low or nonexistent sperm counts and direct injection of the sperm into the egg. Additionally, Silber has studied fertility in animals and performed microscopic surgery on chimpanzees, South American bush dogs, Przewalski's horse, gorillas, wolves, and other endangered species.
Brigham And Women's Hospital
Associate Professor, Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School
Associate Professor, Epidemiology, Harvard T.H. Chan School Of Public Health
Director of Epidemiologic Research in Reproductive Medicine, Obstetrics, Gynecology, Reproductive Biology, Brigham And Women's Hospital
Director, Growing Up Today Study, Channing Laboratory of Network Medicine, Brigham And Women's Hospital
Associate Scientist, Division of Adolescent Medicine, Boston Children's Hospital
Scientific Director, Boston Center for Endometriosis, Obstetrics, Gynecology, Reproductive Biology, Brigham And Women's Hospital
Stacey Missmer, ScD. received her Bachelors degree in Biology from Lehigh University and her Master and Doctor of Science (Sc.D.) degrees in Epidemiology from Harvard School of Public Health. She joined the faculty of Harvard University as an Instructor in 2003 and was promoted to Assistant Professor in Obstetrics, Gynecology, and Reproductive Biology at Harvard Medical School and of Epidemiology at Harvard School of Public Health in 2006 and to Associate Professor in 2012. From 2012 until August 2016, Dr. Missmer was the faculty lead for the Reproductive, Perinatal and Pediatric Epidemiology (RPPE) concentration in the Department of Epidemiology, Harvard T.H. Chan School of Public Health. Also during these years, she was the Director of Epidemiologic Research and the Fellowship Research Director for the Division of Reproductive Medicine and also the Director of the Growing Up Today Study in the Channing Division of Network Medicine at Brigham and Women’s Hospital and Harvard Medical School. In 2016, Dr. Missmer was the first faculty member to be endowed through Michigan State University’s Global Impact Initiative and is currently Professor in the Department of Obstetrics, Gynecology and Reproductive Biology in the College of Human Medicine.
Stacey Missmer joined the Nurses’ Health Study (NHS) Research Group at Harvard University in 1998 initially as a member of Dr. Susan Hankinson’s hormonal markers of breast cancer discovery team. Since then she has been the senior endometriosis investigator with the NHS Research Group. In 2007, Dr. Missmer joined the International Endogene Consortium as the US Principal Investigator - combining resources for GWAS discovery of endometriosis with Australia PI, Dr. Grant Montgomery and UK PI, Dr. Krina Zondervan. In 2012, Dr. Missmer co-founded the Boston Center for Endometriosis with Dr. Marc Laufer, and serves as the Scientific Director where she designed and leads the Women’s Health Study: from Adolescence to Adulthood (A2A) - a multi-hospital and population-based cohort with longitudinal data and biologic sample collection. In 2014 as a member of the World Endometriosis Research Foundation (WERF) Board of Directors, she conceived of and became Co-Principal Investigator with Dr. Zondervan of the Endometriosis Phenome and Biobanking Harmonization Project (EPHect). Dr. Missmer is currently the Chair-elect of the Endometriosis Special Interest Group and also Chair of the Nutrition Special Interest Group for the American Society of Reproductive Medicine (ASRM). Formerly an Associate Editor, she is a member of the Statistical Advisory Board for Human Reproduction and currently serves on the Data Safety and Monitoring Board of the NIH Reproductive Medicine Network (RMN). Author of more than 200 peer reviewed publications, reviews, and book chapters, her research has focused on causes, consequences, and discovery of modifiable factors related to reproductive health.
Much of Dr. Missmer’s research has focused on identifying factors that affect the risk of endometriosis – particularly among young women and girls. Her research team has confirmed or identified variation in the population-based incidence of endometriosis associated with in utero exposures and early life body size, exercise, and dietary intake. Dr. Missmer’s team has been critical in considering validity of study design and analytic approaches, since we are hindered by a potentially large pool of undiagnosed and underserved women and girls given the diagnostic difficulties for endometriosis. In addition, her research suggests that girls and women with endometriosis may be a “high risk” group for autoimmune disease, cardiovascular disease, and specific cancer types – reinforcing the importance of longitudinal discovery. Critical to this discovery is defining and validating endometriosis heterogeneity by applying precision medicine methods that have successfully revolutionized our understanding risk, treatment, and prognosis among cancer subtypes.
This lifecourse and subgroup-centric approach also applies to Dr. Missmer’s second area of research – predictors of infertility, access and response to infertility treatment, and the longterm health of women with infertility. In 1998 she joined Dr. Dan Cramer’s multi-site study of predictors of in vitro fertilization (IVF) outcomes, assuming the role of Principal Investigator in 2006. Within this cohort of nearly 3000 couples undergoing IVF, this team has explored the relations between diet, physical activity, cigarette smoking and caffeine and alcohol consumption on successful conception and livebirth. She has also led the design and analyses for clinical studies of IVF outcomes with Drs. Catherine Racowsky and Elizabeth Ginsburg of the Center for Infertility and Reproductive Surgery at Brigham and Women’s Hospital. Within the Nurses’ Health Study II, her team has evaluated demographic and lifestyle characteristics influencing infertility treatment seeking and exposure patterns. Finally, she continues to collaborate with Dr. Barbara Luke, the senior Society for Assisted Reproductive Technology (SART) epidemiologist, in studies of the relations between infertility, infertility treatment and cancer risk.
DF/HCC PROGRAM AFFILIATION
Cancer Epidemiology, Member
BSc (University of Liverpool)
PhD (University of Liverpool)
I obtained my BSc and PhD at Liverpool. I have worked on ion channels and cell signalling (primarily Ca2+) in the physiology and pathology of a number of cell types. Initially this work was focussed on synaptic transmission, synaptic plasticity and Ca2+-mediated cell death in excitable cells. After moving to Birmingham, I worked on signalling in mammalian bone, particularly the putative glutamatergicsignalling network. My laboratory now concentrates on human sperm physiology and sperm-egg signalling. We are studying signalling events (primarily [Ca2+]isignalling and ion channel regulation) evoked by interaction of sperm with the oocyte-cumulus complex and the female tract.
Areas of teaching include neurobiology and nervous systems (taught to all three undergraduate years), cellular physiology and reproductive biology. I have a background in zoology and also contribute to teaching on animal diversity.
Stine GryKristensen is a Post.doc. at the Laboratory of Reproductive Biology, which she joined in March 2009. She graduated in Biology from the University of Copenhagen in 2009 with a Master in cell and developmental biology, and obtained her PhD degree in June 2013. Her present work focuses on human follicle development and the regulatory mechanisms underlying early folliculogenesis. The Danish cryopreservation programme for ovarian tissue at LRB provides a unique opportunity to work with human ovarian tissue.
In the first part of her PhD Stine has developed a method to isolate preantral human follicles from discarded medulla tissue, and this method enables her to study early follicular development and perform in vitro studies. Currently, Stine is developing a 3D culture system for preantral human follicles and investigating the effect of different gonadotropins and growth factors that possibly influence on follicle growth, survival and maturation in vitro.
Stine is also course-coordinator of The Copenhagen Workshop on Cryopreservation of Ovarian Tissue and chair of ReproYoung (association of young researcher in ReproUnion).
TomerAvidor-Reiss is an Associate Professor at the University of Toledo. His lab is studying how the subcellular organelles centriole, centrosome, and cilium are formed, function, and involved with diseases such as infertility. His lab discoveries include: a new type of centriole – the proximal centriole-like (PCL) in sperm cells; that sperm centriole must be modified to function in the zygote; that Asterless/Cep152 is essential for centriole duplication; that S-CAP complex of PCM proteins is essential for PCM formation; and that tubulin function as a switch protein in centrosome assembly. Tomer has a major interest in inspiring students at all levels to do research, and you are welcome to contact him with any questions you might have in the area. Before joining the University of Toledo, Tomer was at Harvard Medical School in Boston where he was an Assistant Professor and started studying the centrosome. Before that, he was in the University of California San Diego where he performed his Postdoc studies on how the cilium is formed. Before that, he was in Weizmann Institute of Science, in Rehovot, Israel, studying the mechanism of opiate addiction and obtained his Ph.D. Before that, he was at the Hebrew University, in Jerusalem, Israel. There he studied how cells released neurotransmitters to communicate with other cells and obtained his M.Sc. in biochemistry with distinction. There, he also got his B.Sc. All of us started our life as a single cell (the zygote) that was produced when the sperm fertilized the egg. This cell contained all the information to create an adult made of trillions of cells. Most of these adult cells must have two structures known as the centrioles, which are essential for building the cell’s antenna (the cilium) and skeleton (cytoskeleton) as well as for proper cell division. How the zygote got its first two centrioles is a mystery and is the focus of our research. Also, we study the role of the sperm centrioles in infertility.
• Consultant/Senior Lecturer and subspecialist in Reproductive Medicine & Surgery, Guy’s & St. Thomas’ Hospital and King’s College, London.
• Head of Fertility Services and Director of Assisted Conception Unit & Centre for Pre-implantation Genetic Diagnosis.
• Member of the Human Fertilisation& Embryology Authority (HFEA) Board.
• Executive Officer of the British Fertility Society.
• Chair of the Scientific and Clinical Advances Committee of the HFEA.
• Chair of the RCOG National Clinical Studies group in Reproductive Medicine & Surgery.
• Member of the RCOG Research Committee
• Expert advisor to the National Institute for Health Care & Clinical Excellence (NICE).
• Deputy Director of Subspecialty Training Programme in Reproductive Medicine & Surgery.
• Principal Investigators/clinical adviser of several NIHR funded research grants.
• Published widely (>150 Peer reviewed articles) on different aspects of Assisted Conception, Reproductive Medicine & Surgery in major medical journals including NEJM, Lancet, BMJ and Nature Cell Biology, Nature with national and international experience in research degrees supervision and assessment.
• Ex Associate Editor of RBM online Journal.
• Invited speaker on fertility and assisted reproduction in numerous national and international conferences. Expert in fertility service development and service review.