Csilla Krausz Italy

Brief biographical sketch of the Coordinator 1) Graduated at the Faculty of Medicine and Surgery (MD) 110/110 cum laude University of Florence 2) “Specialist in Endocrinology and Metabolic Diseases” Maximum marks cum laude (30/30 cum laude) University of Florence, Faculty of Medicine 70/70 cum laude 3) “Clinical Andrologist” of the European Academy of Andrology 4) PhD in Human Genetics (“Mention Très honorable avec felicitations du Jury”); Université Paris VII, Pasteur Institute, Paris, France; Title of the Thesis: “Y chromosome and male infertility” 5) PhD in “Endocrinology and Metabolism” University of Florence, Faculty of Medicine Member of the scientific board of the Doctorate/PhD Program in : 1) SCIENZE BIOMEDICHE, University of Florence, Italy Member of the following Scientific Societies 1)Academician” of the European Academy of Andrology (EAA) from 2014 President of the EAA 2) Member of the SocietàItaliana di Endocrinologia (SIE) from 2013 member of the Executive committee 3) Member of the SocietàItaliana di AndrologiaMedica e Sessuologia (SIAMS) 4) Honorary Member of the Hungarian Society of Andrology (MATT) 5) Honorary member of the Hungarian Oncology Society (MOT) Member of the editorial board of the following Journals 1) from 2004-2014 International Journal of Andrology (Associate Editor) 2) from 2004-2007 Human Reproduction (Associate Editor) 3) from 2017 Human Andrology (Associate Editor) 4) from 2013 Basic and Clinical Andrology (Associate Editor) 5) from 2014 Andrology (member of the Editorial board) Research Team 1) Vinci Serena, Post-doc, Biotechnologist 2) Guarducci Elena, Biologist 3) Casamonti Elena, PhD-student, Biotechnologist 4) Cioppi Francesca, Master Student, Biotechnologist 5) Fino Maria Grazia, biomedical laboratory technician (onco-andrology, spermatology) 6) Selene Degl’Innocenti, biomedical laboratory technician (Y chromosome analysis) Current research interests The laboratory is dedicated to the identification of genetic factors involved in male infertility, cryptorchidism and testis cancer. The main topics are Y chromosome rearrangements and Y-linked gene copy number variations in relationship with the above pathologies. Given the specific competencies of the laboratory in Y chromosome rearrangements, the laboratory organized a multicenter study aimed to define the genetic determinants for the variable phenotype of gr/gr deletion carriers. The second relevant research topic is on genetic polymorphisms (SNPs, microsatellites and CNVs. A project on X-linked copy number variations, using a high resolution array-CGH, we are able to identify copy number variations (losses and gains) on the X chromosome with potential effect on spermatogenesis. The majority of the research projects performed in this laboratory have a clear translational feature and are aimed to implement the available diagnostic tests in male infertility. Genetic studies in men with impaired spermatogenesis are relevant also for the potential transmission of genetic anomalies to the next generation through Assisted Reproductive Techniques. Studies focusing on genetic factors involved in testis tumors are relevant for the prediction of genetic risk for this disease. An other kind of activity carried out in our laboratory are pharmacogenetic studies on three SNPs on FSH? and FSHR in oligo- and/or astheno- and/or teratozoospermic patients. We are evaluating the effect of cytostatic therapy on the male gamete genome . The ultimate goal of the project is to define reproductive safety in oncological patients and thus provide evidence based information for decision making concerning the type of conception (pre-therapy frozen/thawed spermatozoa in the context of in vitro fertilization) or natural pregnancy (spermatogenesis is recovered in about 80% of patients after chemotherapy). Current / recent sources of funding 1) IstitutoToscanoTumori (ITT) 2) EnteCassa di Risparmio di Firenze (2015) 3) PRIN 2017-2020, Italian Ministry of Instruction and Research